1875036-75-1
1875036-75-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T14569 英文別名
BI8626BI8626 (BI-8626
N-(3-(Aminomethyl)benzyl)-8-(4-benzylpiperazin-1-yl)pyrimido[5,4-d]pyrimidin-4-amine
1,3-Benzenedimethanamine, N1-[8-[4-(phenylmethyl)-1-piperazinyl]pyrimido[5,4-d]pyrimidin-4-yl]-
物理化學(xué)性質(zhì)
沸點654.4±55.0 °C(Predicted)
密度1.302±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 83.33 mg/mL (189.15 mM; Need ultrasonic)
酸度系數(shù)(pKa)9.01±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
化合物 T14569價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-120204 | 化合物 T14569 BI8626 | 1875036-75-1 | 5mg | 2500元 |
| 2024/11/08 | HY-120204 | 化合物 T14569 BI8626 | 1875036-75-1 | 10mM * 1mLin DMSO | 2750元 |
| 2024/11/08 | HY-120204 | 化合物 T14569 BI8626 | 1875036-75-1 | 10mg | 3800元 |
常見問題列表
生物活性
BI8626 是一種泛素連接酶 HUWE1 特異性拮抗劑，IC50 為 0.9 μM。靶點
IC50: 0.9 μM (HUWE1)
體外研究
BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells.
BI8626 suppresses colony formation of Ls174T cells with estimated IC
50
value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1.
BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells.
Cell Cycle Analysis
| Cell Line: | Ls174T cells |
| Concentration: | 0 μM, 5 μM,10 μM, 15 μM, 20 μM |
| Incubation Time: | 0-4 days |
| Result: | Retarded passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1. |
Western Blot Analysis
| Cell Line: | U2OS cells |
| Concentration: | 0 μM, 20 μM, 50 μM |
| Incubation Time: | 0 hour,1 hour,2 hours,4 hours,6 hours |
| Result: | Retarded the degradation of MCL1 in response to UV irradiation in HeLa cells by inhibiting HUWE1 in U2OS cells. |