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1825355-56-3

中文名稱 1825355-56-3
英文名稱 Ribocil-C
CAS 1825355-56-3
分子式 C21H21N7OS
分子量 419.5
MOL 文件 1825355-56-3.mol
1825355-56-3 結(jié)構(gòu)式 1825355-56-3 結(jié)構(gòu)式

基本信息

中文別名
化合物 T12722L
英文別名
Ribocil-C
4(3H)-Pyrimidinone, 2-[(3S)-1-[[1-(2-pyrimidinyl)-1H-imidazol-4-yl]methyl]-3-piperidinyl]-6-(2-thienyl)-

物理化學(xué)性質(zhì)

沸點(diǎn)672.0±65.0 °C(Predicted)
密度1.47±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : ≥ 24.6 mg/mL (58.64 mM)
酸度系數(shù)(pKa)8.44±0.50(Predicted)
形態(tài)Solid
顏色White to off-white
1825355-56-3價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08HY-19488A1825355-56-3
Ribocil-C
1825355-56-35mg900元
2024/11/08HY-19488A1825355-56-3
Ribocil-C
1825355-56-310mM * 1mLin DMSO990元
2024/11/08HY-19488A1825355-56-3
Ribocil-C
1825355-56-310mg1600元

常見問題列表

生物活性
Ribocil-C是高度選擇性的細(xì)菌核黃素核糖開關(guān) (bacterial riboflavin riboswitches) 抑制劑。
靶點(diǎn)

Bacterial riboflavin riboswitches

體外研究

Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch that controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli . Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii , to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth.

體內(nèi)研究

Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) demonstrate a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log 10 [CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed.

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