1820684-31-8
中文名稱(chēng)
化合物 T15943
英文名稱(chēng)
M-443
CAS
1820684-31-8
分子式
C31H30F3N7O2
分子量
589.61
MOL 文件
1820684-31-8.mol
1820684-31-8 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15943 英文別名
M-443M-443 (M443
Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-[1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-2-pyrimidinyl]amino]-
物理化學(xué)性質(zhì)
密度1.34±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 55 mg/mL (93.28 mM)
酸度系數(shù)(pKa)12.95±0.70(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
應(yīng)用領(lǐng)域
用途一
M443 is a specific small molecule inhibitor of MRK. M443 strongly radiosensitizes UW228 medulloblastoma cells as well as UI226 patient-derived primary cells, whereas it does not affect the response to radiation of normal brain cells. M443 also inhibits radiation-induced activation of both p38 and Chk2, two proteins that act downstream of MRK and are involved in DNA damage-induced cell-cycle arrest.