1802997-81-4
中文名稱
SEC
英文名稱
1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
CAS
1802997-81-4
分子式
C22H23ClN2O5
分子量
430.88
MOL 文件
1802997-81-4.mol
1802997-81-4 結(jié)構(gòu)式
基本信息
中文別名
金黃色葡萄球菌腸毒素C(SEC)ELISA試劑盒 英文別名
SEC1H-Pyrazole-5-carboxylic acid, 1-[(2S)-3-(4-chlorophenoxy)-2-hydroxypropyl]-3-(4-methoxyphenyl)-, ethyl ester
物理化學(xué)性質(zhì)
沸點(diǎn)627.7±55.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)13.31±0.20(Predicted)
形態(tài)Oil
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
SEC 通過(guò) AMPK/mTORC1/STAT3 信號(hào)通路誘導(dǎo) ANXA7 GTPase 的激活。SEC 選擇性的促進(jìn)癌細(xì)胞的凋亡，誘導(dǎo) ITGB4 核轉(zhuǎn)位，表達(dá)高水平 ITGB4。體外研究
SEC (20 μM) inhibits the cell migration of HEK 293T RKIP
?/?
cells and PC3 prostate cancer cells.
SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (
cell selectively
).
Cell Viability Assay
| Cell Line: | HEK293T RKIP ?/? cells. [1] |
| Concentration: | 20 μM. |
| Incubation Time: | 24 h. |
| Result: | Suppressed HEK293T RKIP ?/? cell migration while had no effect on HEK293T RKIP +/+ cells. |
體內(nèi)研究
SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model.
| Animal Model: |
Luciferase-labeled PC-3M-Luc cells (2×10
6
per 50 μL sterile HBSS
?/?
) are orthotopically inoculated into the prostates of 8-week-old nude mice.
|
| Dosage: | 3 mg/kg/day or 18 mg/kg/day. |
| Administration: | IP daily for 3 weeks. |
| Result: |
Suppressed the lymph node metastatic capacities of PC-3M-Luc cells in the nude mice model.
Decreased the mRNA level of CCL2 , APLN and IL6ST in implanted tumors. Did not affect the body weight of the mice. |