1781934-47-1
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2024/11/08 | S0080 | SNAP 94847 (hydrochloride) SNAP94847 hydrochloride | 1781934-47-1 | 5mg | 2596.23元 |
2024/11/08 | S0080 | SNAP 94847 (hydrochloride) SNAP94847 hydrochloride | 1781934-47-1 | 25mg | 7854.21元 |
常見問題列表
Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)
SNAP 94847 hydrochloride (oral gavage; 20?mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment:?F(2,19)=11.31,?treatment?×?time:?F(34,323)?=?4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals. SNAP 94847 hydrochloride (oral administration; 20?mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment:?F(3,28)?=?8.971; treatment?×?time:?F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40?min in the SNAP 94847-treated group,this effect is significant over 180?min. SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study.
Animal Model: | Rat |
Dosage: | 20 mg/kg |
Administration: | Oral administration; 20 mg/kg; 14 days |
Result: | Exhibited a exaggerated locomotor response to acute quinpirole. |
Animal Model: | Rat |
Dosage: | 10 mg/kg |
Administration: | Oral administration; 10 mg/kg |
Result: | Exhibited good physicochemical properties in rats. |