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1781934-47-1

中文名稱 SNAP 94847 (hydrochloride)
英文名稱 SNAP 94847 (hydrochloride)
CAS 1781934-47-1
更新日期 2023/03/20 15:41:19
分子式 C29H33ClF2N2O2
分子量 515.04
MOL 文件 1781934-47-1.mol
1781934-47-1 結(jié)構(gòu)式 1781934-47-1 結(jié)構(gòu)式

基本信息

中文別名
化合物SNAP 94847 HYDROCHLORIDE
英文別名
SNAP 94847 HCL

物理化學(xué)性質(zhì)

溶解度Soluble to 100 mM in DMSO and to 100 mM in ethanol
形態(tài)Solid
顏色White to light yellow
SNAP 94847 (hydrochloride)價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08S0080SNAP 94847 (hydrochloride)
SNAP94847 hydrochloride
1781934-47-15mg2596.23元
2024/11/08S0080SNAP 94847 (hydrochloride)
SNAP94847 hydrochloride
1781934-47-125mg7854.21元

常見問題列表

生物活性
SNAP 94847 hydrochloride 是一種具有抗抑郁樣活性的新型高親和力選擇性黑色素濃縮激素受體1 (MCHR1) 拮抗劑。SNAP 94847 hydrochloride 以高親和力結(jié)合大小鼠 MCHR1,與其他 GPCR,離子通道,酶和轉(zhuǎn)運(yùn)蛋白具有最小的交叉反應(yīng)性。SNAP 94847 hydrochloride 是 MCH 誘發(fā)的肌醇磷酸形成的高親和力拮抗劑 (pA2=7.81)。
靶點(diǎn)

Ki: 2.2 nM (MCHR1); Kd: 530 pM (MCHR1)

體內(nèi)研究

SNAP 94847 hydrochloride (oral gavage; 20?mg/kg; 14 days) shows an exaggerated locomotor response to acute quinpirole [treatment:?F(2,19)=11.31,?treatment?×?time:?F(34,323)?=?4.061], the effect of SNAP 94847 on quinpirole-evoked ambulations over the entire observation period is significant compared to the untreated animals. SNAP 94847 hydrochloride (oral administration; 20?mg/kg; 21 days) in drink water, produces a significant increase in ambulation relative to untreated animals [treatment:?F(3,28)?=?8.971; treatment?×?time:?F(51,476)=11.50]. shows a marked increase in locomotion is apparent after 40?min in the SNAP 94847-treated group,this effect is significant over 180?min. SNAP 94847 hydrochloride (oral administration; 10 mg/kg), has a good bioavailability (59%), low plasma and blood clearances of 4.2 L/hr/kg and 3.3 L/hr/kg, respectively, and the half-life was shown to be 5.2 h in rats in a PK study.

Animal Model: Rat
Dosage: 20 mg/kg
Administration: Oral administration; 20 mg/kg; 14 days
Result: Exhibited a exaggerated locomotor response to acute quinpirole.
Animal Model: Rat
Dosage: 10 mg/kg
Administration: Oral administration; 10 mg/kg
Result: Exhibited good physicochemical properties in rats.
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