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1776060-36-6

英文名稱(chēng) Methanone, [(2S)-5-(cyclobutyloxy)-3,4-dihydro-2-methyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-1(2H)-quinolinyl]cyclopropyl-
CAS 1776060-36-6
分子式 C26H34N4O2
分子量 434.57
MOL 文件 1776060-36-6.mol
1776060-36-6 結(jié)構(gòu)式 1776060-36-6 結(jié)構(gòu)式

基本信息

英文別名
Methanone, [(2S)-5-(cyclobutyloxy)-3,4-dihydro-2-methyl-6-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-1(2H)-quinolinyl]cyclopropyl-

應(yīng)用領(lǐng)域

用途一
FT-1101 is an orally bioavailable, potent and selective BET inhibitor. FT-1101 binds to the acetylated lysine recognition motifs in the bromodomain sites of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to the inhibition of tumor cell growth. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth.
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