17466-45-4
中文名稱
毒蠅虎蕈鹼
英文名稱
PHALLOIDIN
CAS
17466-45-4
分子式
C35H48N8O11S
分子量
788.87
MOL 文件
17466-45-4.mol
更新日期
2024/12/18 11:18:05
17466-45-4 結(jié)構(gòu)式
基本信息
中文別名
毒傘素鬼筆環(huán)肽
毒蠅虎蕈鹼
鬼筆環(huán)肽 來源于鬼筆鵝膏
英文別名
Nsc523214PHALLOIDIN
phalloidine
PHALLOIDIN, AMANITA PHALLOIDES
PHALLOIDIN FROM AMANITA PHALLOIDES
pto-l-tryptophyl-4,5-dihydroxy-l-leucyl),cyclic(3,6)-sulfide
Cyclo(L-Ala-D-Thr-L-Cys(1)-L-c4Hyp-L-Ala-L-Trp2(1)-4,5'-dihydroxy-L-Leu-)
cyclic(l-alanyl-d-threonyl-l-cysteinyl-cis-4-hydroxy-l-prolyl-l-alanyl-2-merca
Cyclic(L-alanyl-D-threonyl-L-cysteinyl-cis-4-hydroxy-L-prolyl-L-alanyl-2-mercapto-L-tryptophyl-4,5-dihydroxy-L-leucyl), cyclic (3.fwdarw.6)-sulfide
所屬類別
生物化工：多肽物理化學(xué)性質(zhì)
熔點280-282°
比旋光度+55.7°(D/20℃)(c=0.5,メタノール)
密度1.1612 (rough estimate)
折射率1.7400 (estimate)
儲存條件+2C to +8C
溶解度DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Water: 0.5 mg/ml (warm)
沸點1370.5±65.0 °C(Predicted)
酸度系數(shù)(pKa)13.03±0.70(Predicted)
形態(tài)白色結(jié)晶固體
顏色針狀或結(jié)晶狀
水溶解性Soluble to 1 mg/ml in water
Merck13,7273
BRN4347460
穩(wěn)定性穩(wěn)定的。與強氧化劑不相容。
安全數(shù)據(jù)
警示詞危險
危險性描述H300+H310+H330
危險品標(biāo)志T+
危險類別碼26/27/28
安全說明22-28-36/37-45
危險品運輸編號UN 3462 6.1/PG 2
危險品運輸編號UN 3462 6.1/PG 2
WGK Germany3
WGK Germany3
RTECS號SE9800000
F18
危險等級6.1(a)
包裝類別I
海關(guān)編碼2934999090
毒害物質(zhì)數(shù)據(jù)17466-45-4(Hazardous Substances Data)
毒性LD50 i.m. in albino mice: 3.3 mg/g (Vogt); LD50 i.p. in mice: 2 mg/kg (Wieland, Wieland)
常見問題列表
生物活性
Phalloidin 是一種蘑菇衍生的毒素，可以與熒光染料結(jié)合來標(biāo)記細胞骨架的 F-肌動蛋白 (λex=495 nm， λem=520 nm)。體外研究
Phalloidin staining will not work with methanol-fixed cells, probably because of the disruption of actin filament integrity, but it will work with cells fixed in 0.2% glutaraldehyde in PBS. For fluorescein isothiocyanate (FITC)-Phalloidin (or rhodamine isothiocyanate [RITC]-Phalloidin), the excitation wavelength maximum will be near 495 nm (or 550 nm) and the emission wavelength maximum will be ~520 nm based on H 2 O at pH 8.0 as the solvent (575 nm with methanol as the solvent). The emission spectrum of fluorescein can depend on the environmental pH and/or ionic strength.