173528-92-2
基本信息
HMN-154游離態(tài)
HMN 154
HMN154
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E
(E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine
Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2023/01/06 | S0288 | 173528-92-2 HMN-154 | 173528-92-2 | 5mg | 3824.73元 |
2023/01/06 | S0288 | 173528-92-2 HMN-154 | 173528-92-2 | 25mg | 11539.7元 |
常見問題列表
IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)
HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC 50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.