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173528-92-2

中文名稱 173528-92-2
英文名稱 (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine
CAS 173528-92-2
分子式 C20H18N2O3S
分子量 366.43
MOL 文件 173528-92-2.mol
更新日期 2024/12/15 19:35:15
173528-92-2 結(jié)構(gòu)式 173528-92-2 結(jié)構(gòu)式

基本信息

中文別名
化合物HMN154
HMN-154游離態(tài)
英文別名
HMN-154
HMN 154
HMN154
2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E
(E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine
Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-

物理化學(xué)性質(zhì)

沸點553.7±60.0 °C(Predicted)
密度1.313±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,Room Temperature
溶解度DMSO:15.0(Max Conc. mg/mL);40.93(Max Conc. mM)
酸度系數(shù)(pKa)8.09±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
173528-92-2價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/01/06S0288173528-92-2
HMN-154
173528-92-25mg3824.73元
2023/01/06S0288173528-92-2
HMN-154
173528-92-225mg11539.7元

常見問題列表

生物活性
HMN-154是一種新型的苯磺酰胺類抗癌化合物。HMN-154與NF-YB相互作用,從而中斷NF-Y異源三聚體與DNA的結(jié)合。
靶點

IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)

體外研究

HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC 50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.

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