1714114-25-6
中文名稱
索非布韋雜質2
英文名稱
(R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate
CAS
1714114-25-6
分子式
C18H17F5NO7P
分子量
485.296
MOL 文件
1714114-25-6.mol
1714114-25-6 結構式
基本信息
中文別名
索福斯布韋雜質V索福斯布韋雜質2
(R)-異丙基2-((((S)-(全氟苯氧基)(苯氧基)磷酰基)氨基)丙酸酯
英文別名
(R)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate應用領域
用途一
N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-D-alanine 1-Methylethyl Ester is an impurity of PSI-7977 (P839640); a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.