170846-89-6
中文名稱
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID
英文名稱
E4CPG
CAS
170846-89-6
分子式
C11H13NO4
分子量
223.23
MOL 文件
170846-89-6.mol
更新日期
2025/01/07 00:59:10
170846-89-6 結(jié)構(gòu)式
基本信息
中文別名
化合物E4CPG 英文別名
E4CPG(RS)-α-Ethyl-4-carboxyphenylglycine
4-(1-amino-1-carboxypropyl)benzoic acid
(RS)-ALPHA-ETHYL-4-CARBOXYPHENYLGLYCINE
Benzeneacetic acid, α-amino-4-carboxy-α-ethyl-
物理化學(xué)性質(zhì)
沸點(diǎn)431.3±40.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
儲(chǔ)存條件Store at RT
溶解度H2O : < 0.1 mg/mL (insoluble)DMSO : < 1 mg/mL (insoluble or slightly soluble)
酸度系數(shù)(pKa)1.76±0.10(Predicted)
形態(tài)粉末
顏色White to off-white
4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 5mg | 600元 |
| 2024/11/08 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 10mg | 800元 |
| 2024/11/08 | HY-100372 | 4-(1-AMINO-1-CARBOXYPROPYL)BENZOIC ACID E4CPG | 170846-89-6 | 25mg | 1800元 |
常見問題列表
生物活性
E4CPG ((RS)-ECPG) 是一種 Group I/Group II 代謝型谷氨酸受體 (Group I/Group II metabotropic glutamate receptor) 的拮抗劑。E4CPG 可以抑制單突觸后機(jī)制中突觸后電流 (IPSC) 增強(qiáng)的成對(duì)脈沖比。靶點(diǎn)
|
mGluR
|
體外研究
E4CPG acts at rat cortical mGluR with the K B value of 0.367 mM.
體內(nèi)研究
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) .
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.
| Animal Model: | Male Swiss mice (25-35 g) |
| Dosage: | 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.) |
| Administration: | Single injection |
| Result: | The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.). |
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 35 nM/3.5 μL |
| Administration: | Single injection, i.c.v. |
| Result: | Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG). |