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170809-51-5

中文名稱 ASTRESSIN
英文名稱 ASTRESSIN
CAS 170809-51-5
分子式 C161H269N49O42
分子量 3563.16
MOL 文件 170809-51-5.mol
更新日期 2025/04/06 20:40:30
170809-51-5 結(jié)構(gòu)式 170809-51-5 結(jié)構(gòu)式

基本信息

中文別名
收斂素
NLE-ASTRESSIN
NLE-ASTRESSIN拮抗劑多肽
英文別名
ASTRESSIN
ASTRESSIN (HUMAN, RAT)
Astressin >=90% (HPLC)
M.W. 3563.24 C161H269N49O42
ASTRESSIN TRIFLUOROACETATE SALT
[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41) (HUMAN, RAT)
[D-PHE12, NLE21,38, GLU30, LYS33]-CRF (12-41), CYCLIC LACTAM, HUMAN, RAT
[D-PHE12,NLE21,38,GLU30,LYS33]-CORTICOTROPIN RELEASING FACTOR FRAGMENT 12-41
(D-PHE12,NLE21,38,GLU30,LYS33)-CRF (12-41) (HUMAN, RAT) TRIFLUOROACETATE SALT
[D-PHE12, NLE21,38, GLU30, LYS33]-CORTICOTROPIN RELEASING FACTOR (12-41) (HUMAN, RAT)

物理化學性質(zhì)

密度1.43±0.1 g/cm3(Predicted)
儲存條件−20°C
儲存條件−20°C
溶解度H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution:
形態(tài)粉末
顏色White to off-white
水溶解性Soluble to 1 mg/ml in 10% Acetic acid / water
序列H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Glu-Ala-His-Lys-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
ASTRESSIN價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-P0257ASTRESSIN
Astressin
170809-51-51mg1080元
2025/02/08HY-P0257ASTRESSIN
Astressin
170809-51-55mg2704元
2025/02/08HY-P0257Astressin170809-51-510 mg4320元

常見問題列表

生物活性
Astressin是有效的促腎上腺皮質(zhì)激素釋放因子 (CRF) 拮抗劑。
體外研究

Astressin has low affinity for the CRF binding protein and high affinity (K i =2 nM) for the cloned pituitary receptor. Astressin shows high affinity for cloned human CRF-RA1 stably expressed in CHO cells and high potency to inhibit ACTH secretion.

體內(nèi)研究

Astressin is significantly more potent than any previously tested antagonist in reducing hypophyseal corticotropin (ACTH) secretion in stressed or adrenalectomized rats. Low doses of astressin (30 μg and 100 μg per kg) administered i.v. still produce a significant decrease in ACTH levels at 45 and 90 min, respectively. Astressin significantly reverses the anxiogenic-like response induced by both social stress and ICV rat/humanCRF (r/hCRF) on the elevated plus-maze, but fails to block the effects of r/hCRF-induced locomotor activity in a familiar environment. Intracerebroventricular infusion of the peptide both 30 min before and 10 min after seizures decreases damage in some hippocampal cell fields by as much as 84%, a magnitude of protection greater than reported for other CRF antagonists against other models of necrotic neuronal injury. Astressin protects even if administered only 10 min following excitotoxin exposure.

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