170365-25-0
中文名稱
170365-25-0
英文名稱
KW-8232 free base
CAS
170365-25-0
分子式
C36H37ClN4O3
分子量
609.16
MOL 文件
170365-25-0.mol
170365-25-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T11792 英文別名
KW-8232 free baseMethanone, [3-[bis(4-hydroxyphenyl)methyl]-1-[2-(dimethylamino)ethyl]-1H-indol-2-yl][4-(2-chlorophenyl)-1-piperazinyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)805.5±65.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)9.95±0.10(Predicted)
形態(tài)Solid
顏色Off-white to pink
170365-25-0價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-100304 | 170365-25-0 KW-8232 free base | 170365-25-0 | 1mg | 8500元 |
常見問題列表
生物活性
KW-8232 free base 是一種抗骨質(zhì)疏松劑，可以減少前列腺素 PGE2 的生物合成。靶點(diǎn)
Prostaglandin Receptor
體外研究
KW-8232 free base is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE 2 in mouse osteoblastic cells.
體內(nèi)研究
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.