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16994-56-2

中文名稱(chēng) 利血平鹽酸鹽
英文名稱(chēng) reserpine hydrochloride
CAS 16994-56-2
分子式 C33H41ClN2O9
分子量 645.14
MOL 文件 16994-56-2.mol
16994-56-2 結(jié)構(gòu)式 16994-56-2 結(jié)構(gòu)式

基本信息

中文別名
利血平鹽酸鹽
英文別名
Reserpine HCl
reserpine hydrochloride

物理化學(xué)性質(zhì)

儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
溶解度≥25 mg/mL in DMSO; insoluble in H2O; ≥2.74 mg/mL in EtOH with gentle warming and ultrasonic
形態(tài)固體
顏色Light yellow to yellow
利血平鹽酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08HY-N0480A利血平鹽酸鹽
Reserpine hydrochloride
16994-56-2100mg500元
2024/11/08HY-N0480A利血平鹽酸鹽
Reserpine hydrochloride
16994-56-210mM * 1mLin DMSO550元

常見(jiàn)問(wèn)題列表

生物活性
Reserpine (hydrochloride) 是囊泡單胺轉(zhuǎn)運(yùn)蛋白 2 (VMAT2) 的抑制劑。
靶點(diǎn)

VMAT2

體外研究

Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). Reserpine hydrochloride displays a significant on the density of dopamine D1 receptors (F 2,12 =8.81, p<0.01) in the rat striatum. The affinity (Kd) for the dopamine D1 and D2 receptors during withdrawal from acute and chronic administration of reserpine is not change. IC 50 values of 43.9 and 54.9 μM are obtained after 1 day of treatment with Reserpine hydrochloride in JB6 P+ and HepG2-C8 cells, respectively. Reserpine hydrochloride induces luciferase activity in a dose-dependent manner at concentrations ranging from 5 to 50 μM, and no significant induction is observed at concentrations lower than 5 μM. Results demonstrate that Reserpine hydrochloride (2.5 to 10 μM) also increases the protein expression of Nrf2, HO-1, and NQO1. Reserpine hydrochloride at concentrations of 2.5 to 10 μM decreases the mRNA expression of DNMT1, DNMT3a, and DNMT3b in a concentration-dependent manner in JB6 P+ cells after 7 days of treatment. Reserpine hydrochloride at 10 μM generates a significant difference for DNMT3a expression (p<0.05).

體內(nèi)研究

Withdrawal (48 h) from chronic (14-day) but not acute Reserpine hydrochloride administration in a dose of 0.2 mg/kg i.p. produces a significant reduction of the immobility time (F 2,18 =3.68, p<0.05), but increases the climbing time (F 2,18 =4.48, p<0.02), and does not change the swimming time (F 2,18 =1.78; NS) in the forced swim test (FST) in rats. Reserpine hydrochloride at a dose of 5 mg/kg body weight produces significant increase in the urinary excretion profile of vanillylmandelic acid (VMA) compare to control animals. The amount of 5-hydroxyindoleacetic acid (5-HIAA) excreted in animals treated with Reserpine is found to be more than in the control. Dose dependent hypotension is observed with Reserpine hydrochloride. Reserpine hydrochloride at doses of 0.5, 1, 5, 10 and 15 μg/kg produce significant (p<0.01) reduction in blood pressure compare to control.

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