167011-22-5
中文名稱
CP-96021 HYDROCHLORIDE
CAS
167011-22-5
167011-22-5 結(jié)構(gòu)式
常見問題列表
生物活性
CP-96021 hydrochloride 是一種平衡，有效的口服活性白三烯 D4 (LTD4)/血小板活化因子 (PAF) 受體拮抗劑，Ki 值分別為 34 nM 和 37 nM。靶點(diǎn)
|
LTC 4 34 nM (Ki) |
Platelet activating factor (PAF) receptor 37 nM (Ki) |
體內(nèi)研究
In vivo, CP-96021 inhibits iv LTD4- and iv PAF-induced bronchoconstriction in guinea pigs with ED 50 s of 0.46 and 0.16 mg/kg p.o. respectively. CP-96021 effectively blocks the combined airway obstructive effects of endogenously released PAF and LTD4 stimulated by aerosolized antigen challenge in guinea pigs with an ED 50 s of 1.8 mg/kg p.o.