1643947-30-1
中文名稱
ZEN 3694
英文名稱
1H-Imidazo[4,5-b]pyridin-2-amine, 6-(3,5-dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)-
CAS
1643947-30-1
分子式
C19H19N5O
分子量
333.39
MOL 文件
1643947-30-1.mol
1643947-30-1 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)539.0±60.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)7.38±0.30(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
應(yīng)用領(lǐng)域
用途一
ZEN-3694 is an orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ZEN-3694 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression.