1632236-44-2
中文名稱
KLH45
英文名稱
KLH45
CAS
1632236-44-2
分子式
C24H25F3N4O2
分子量
458.48
MOL 文件
1632236-44-2.mol
更新日期
2024/12/16 15:20:12
1632236-44-2 結(jié)構(gòu)式
基本信息
中文別名
化合物 T24263 英文別名
KLH45KLH45 >=98% (HPLC)
N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide
物理化學(xué)性質(zhì)
沸點561.0±60.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
溶解度DMSO:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);65.43(Max Conc. mM)
酸度系數(shù)(pKa)-1.76±0.20(Predicted)
形態(tài)Solid-Liquid Mixture
顏色Off-white to light yellow
常見問題列表
生物活性
KLH45 是有效、選擇性的 DDHD2 抑制劑，其 IC50 值為 1.3 nM。體外研究
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.
KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.
Cell Viability Assay
| Cell Line: | COS-7 cells. |
| Concentration: | 2 μM. |
| Incubation Time: | 16 h. |
| Result: | Selectively blocked DDHD2 activity. |
體內(nèi)研究
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2
?/?
mice.
| Animal Model: |
Mice.
|
| Dosage: | 5-40 mg/kg. |
| Administration: | IP, once. |
| Result: |
Did not show altered brain TAGs.
|