1631164-24-3
1631164-24-3 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
BAY-784 是一種促性腺激素釋放激素受體 (GnRH-R) 拮抗劑探針，對(duì)人和大鼠 GnRH-R 的 IC50 分別為 21 和 24 nM。靶點(diǎn)
IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)
體內(nèi)研究
BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner.
| Animal Model: | OVX rats |
| Dosage: | 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis) |
| Administration: | Single p.o. |
| Result: |
ED
50
=4.5 mg/kg (4/8 h).
The t 1/2 =13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively. |