1628502-91-9
1628502-91-9 結構式
基本信息
Pyridazine, 6-(4-methyl-1-piperazinyl)-3-(2-naphthalenyl)-4-(4-pyridinyl)-
物理化學性質
常見問題列表
|
p38α 101 nM (Ki) |
MW-150 inhibits in a concentration-dependent manner the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia.
MW-150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC
50
values are 332 nM and 936 nM for MK2 and IL-1β, respectively.
MW-150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests.
MW-150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APP
NLh/NLh
× PS
P264L/P264L
knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice.
| Animal Model: | APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta) |
| Dosage: | 2.5 mg/kg |
| Administration: | Oral daily; 3-4 months (until cognitive impairment is present) |
| Result: | Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests. |