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1621717-95-0

中文名稱 SPACE peptide
英文名稱 SPACE peptide
CAS 1621717-95-0
分子式 C??H??N??O??S?
分子量 1090.15
1621717-95-0 結構式 1621717-95-0 結構式

基本信息

中文別名
SPACE肽
H-ALA-CYS-THR-GLY-SER-THR-GLN-HIS-GLN-CYS-GLY-OH(DISULFIDE BRIDGE:CYS2-CYS10)
英文別名
SPACE peptide
SPACE peptide,AC-TGSTQHQ-CG,Disulfide Bridge 2–10
所屬類別
生物化工:多肽

物理化學性質

沸點1870.9±65.0 °C(Predicted)
密度1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
酸度系數(pKa)3.57±0.10(Predicted)
形態(tài)Solid
顏色White to off-white

常見問題列表

生物活性
SPACE peptide 是一種皮膚穿透肽 (SPPs)。SPACE peptide 能增強大分子透明質酸的局部傳遞。
體外研究

SPACE peptide, when conjugates to cargoes such as small molecules and proteins, is able to facilitate their penetration across the stratum corneum into epidermis and dermis.
SPACE peptide also exhibits increased penetration into various cells including keratinocytes, fibroblasts, and endothelial cells, likely through a macropinocytosis pathway.
SPACE peptide enhances Cyclosporine A skin penetration, via a transcellular pathway, enhancing its partitioning into keratin-rich corneocytes through concurrent binding of SPACE with keratin and Cyclosporine A.

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