159432-28-7
基本信息
化合物A 779(3TFA)
(D-ALA7)-血管緊張素I
5-L-異亮氨酸-7-D-丙氨酸-1-7-血管緊張素 II
DRVYIHA
A 779(3TFA)
A 779?, >98%
ASP-ARG-VAL-TYR-ILE-HIS-D-ALA
(D-ALA7)-ANGIOTENSIN I/II (1-7)
Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH
H-ASP-ARG-VAL-TYR-ILE-HIS-D-ALA-OH
(D-Ala7)-Angiotensin I/II (1-7) A-779
5-L-Isoleucine-7-D-Alanine-1-7-Angiotensin II
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | A3281 | A-779 A-779 | 159432-28-7 | 25mg | 405元 |
2024/11/08 | A3281 | A-779 A-779 | 159432-28-7 | 100mg | 1615元 |
常見問題列表
A-779 inhibits the effect of Ang-(1-7), which suppresses the proliferating cell nuclear antigen (PCNA) protein expression up-regulated by Ang II, but A-779 alone has no effect to induce proliferation and migration of VSMCs. Pretreatment with Ang-(1-7) significantly retards Ang II-induced inflammatory responses of VSMCs associated with up-regulated MCP-1, VCAM-1 and IL-1β expressions, and this effect of Ang-(1-7) is blocked by A-779. But A-779 alone has no effect to induce inflammatory response of VSMCs. Pretreatment VSMCs with Ang-(1-7) for 5?min significantly inhibits Akt and ERK1/2 phosphorylation induced by Ang II, and this effect is also blocked by A-779, but alone has no effect to induce phosphorylation of Akt and ERK1/2 in VSMCs.
Infusion of Ang(1-7) and A-779 (400?ng/kg/min, s.c.) alone or combined for 6 weeks does not prevent uterus atrophy or inhibit the body weight gain of OVX rats. A-779 markedly elevates serum bone specific alkaline phosphatase (BALP), telopeptides of collagen type I (CTX), tartarate resistant acid phosphatase (TRAcP 5b), osteocalcin (OC) and urinary deoxypyridinoline (DPD). Infusion of Ang(1-7) and/or A-779 does not significantly change serum minerals concentrations in sham or OVX groups. A-779 in the OVX animals does not change AngII, Ang(1-7), AT1R, AT2R, ACE, ACE-2, Mas receptor, RANKL and OPG proteins expressions in relation to OVX group, while AngII (P [1] . Inhibition of Ang1-7 cascade by A-779 (400?ng/kg/min) significantly eradicates captopril protective effects on bone metabolism, mineralization and micro-structure. A-779 also restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade and down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway.