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159147-88-3

中文名稱 H-PRO-HIS-CYS-LYS-ARG-MET-OH
英文名稱 H-PRO-HIS-CYS-LYS-ARG-MET-OH
CAS 159147-88-3
分子式 C31H54N12O7S2
分子量 770.97
MOL 文件 159147-88-3.mol
更新日期 2024/12/23 10:30:26
159147-88-3 結(jié)構(gòu)式 159147-88-3 結(jié)構(gòu)式

基本信息

中文別名
抗氧化肽 A
(2S)-2-[[(2S)-2-[[(2S)-6-AMINO-2-[[(2R)-2-[[(2S)-3-(1H-IMIDAZOL-5-YL)-2-[[(2S)-PYRROLIDINE-2-CARBONYL]AMINO]PROPANOYL]AMINO]-3-SULFANYLPROPANOYL]AMINO]HEXANOYL]AMINO]-5-(DIAMINOMETHYLIDENEAMINO)PENTANOYL]AMINO]-4-METHYLSULFANYLBUTANOIC ACID
英文別名
PHCKRM
ANTIOXIDANT PEPTIDE A
H-PRO-HIS-CYS-LYS-ARG-MET-OH
(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2R)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylsulfanylbutanoicacid
H-Pro-His-Cys-Lys-Arg-Met-OH?/(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2R)-2-[[(2S)-3-(1H-imidazol-5-yl)-2-[[(2S)-pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylsulfanylbutanoic acid

物理化學(xué)性質(zhì)

密度1.51±0.1 g/cm3(Predicted)
儲存條件-15°C
酸度系數(shù)(pKa)3.22±0.10(Predicted)
序列H-Pro-His-Cys-Lys-Arg-Met-OH
抗氧化肽A價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2023/03/20HY-P1512H-PRO-HIS-CYS-LYS-ARG-MET-OH
Antioxidant peptide A
159147-88-31mg900元
2023/03/20HY-P1512H-PRO-HIS-CYS-LYS-ARG-MET-OH
Antioxidant peptide A
159147-88-35mg2700元
2023/03/20HY-P1512H-PRO-HIS-CYS-LYS-ARG-MET-OH
Antioxidant peptide A
159147-88-310mg4400元

常見問題列表

生物活性
Antioxidant peptide A 是一種短肽。作用于癌細(xì)胞時,Antioxidant peptide A 的側(cè)鏈有助于增強自由基清除活性。
體外研究

The effects of 10-100 μM of Antioxidant peptide A (Pep-A) concentrations are studied on the superoxide dismutase (SOD) enzyme activity. The enzyme activity decreases by 0.5 and 0.7-folds at 10 and 50 μM Antioxidant peptide A concentrations, respectively, and increases by 1.79-folds at 100 μM Antioxidant peptide A treatment, indicating that this concentration can be ideal for the treatment on Y79 a, RB cells. Furthermore, the Antioxidant peptide A can be involved in decreasing the ROS by increasing the antioxidant enzyme activity. A similar increase in the antioxidative enzyme levels in the presence of Hoki skin antioxidative peptide in hepatocarcinoma cells is attributed to the peptide’s role in maintaining the redox balance in the cellular environment. Cell viability analysis results show that the Antioxidant peptide A shows no toxicity to cancerous (Y79) cells and non-cancerous cells even after 48 h of treatment. The Y79 RB cell viability ranges between 115 and 157 % and 111-126 % after 24 and 48 h of exposures with Antioxidant peptide A, respectively. The cancer cell death from the treatment of 10-100 μM GNPs concentration is studied.

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