158959-32-1
158959-32-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12860 英文別名
SC57666Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]-
物理化學(xué)性質(zhì)
熔點(diǎn)146-147 °C
沸點(diǎn)472.1±45.0 °C(Predicted)
密度1.253±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: ≥ 100 mg/mL (316.07 mM)
形態(tài)Solid
顏色White to off-white
158959-32-1價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 1mg | 2400元 |
| 2024/11/08 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 5mg | 5200元 |
| 2024/11/08 | HY-U00129 | 158959-32-1 SC57666 | 158959-32-1 | 10mM * 1mLin DMSO | 5720元 |
常見問題列表
生物活性
SC57666是選擇性的 COX2 抑制劑，IC50 值為26 nM。靶點(diǎn)
|
COX-2 26 nM (IC 50 ) |
體外研究
SC57666 inhibits COX2 with an IC 50 of 3.2±0.8 nM in CHO cells stably transfected with human COX isozymes, with 1000 fold or more selectivity over COX1 (IC 50 =6000±1900 nM).
體內(nèi)研究
SC57666 has been shown to be orally active (ED 50 =1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk.