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158810-73-2

中文名稱 多西他賽雜質(zhì)D
英文名稱 10-O-2,2-Dichloroethoxycarbonyl Docetaxe
CAS 158810-73-2
分子式 C46H55Cl2NO16
分子量 948.84
MOL 文件 158810-73-2.mol
更新日期 2024/01/11 09:47:34
158810-73-2 結(jié)構(gòu)式 158810-73-2 結(jié)構(gòu)式

基本信息

中文別名
多西他賽雜質(zhì)1
多西他賽雜質(zhì)D
10-雙氯乙氧羰基-多西他賽
10-雙氯乙氧羰基-多西他賽 D434415
(N-Formyl -10-deacetyl-N-debenzoylpaclitaxel(USP中N-Formyl impurity)
英文別名
10- Dec Docetaxel
Docetaxel Impurity 15
10-Dichloroethoxycarbonyl docetaxel
6-Dichloroethoxy-carbonyl docetaxel
10-O-2,2-Dichloroethoxycarbonyl Docetaxe
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-6-[[(2,2-dichloroethoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4...
Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-6-[[(2,2-dichloroethoxy)carbonyl]oxy]-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

沸點(diǎn)985.9±65.0 °C(Predicted)
密度1.42±0.1 g/cm3(Predicted)
溶解度Chloroform (Slightly), Methanol (Slightly)
酸度系數(shù)(pKa)11.20±0.46(Predicted)
形態(tài)Solid
顏色White to Off-White
穩(wěn)定性Hygroscopic

應(yīng)用領(lǐng)域

用途一
10-O-2,2-Dichloroethoxycarbonyl Docetaxel is an impurity of Docetaxel (D494420); an antineoplastic and antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.Docetaxel Impurity 1.
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