153322-06-6
中文名稱
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR
英文名稱
Lanicemine dihydrochloride
CAS
153322-06-6
分子式
C13H16Cl2N2
分子量
234.73
MOL 文件
153322-06-6.mol
153322-06-6 結(jié)構(gòu)式
基本信息
中文別名
拉尼西明二鹽酸鹽 英文別名
AZD6765ARL-15896
Lanicemine 2HCl
AZD6765 dihydrochloride
Lanicemine hydrochloride
FPL 15896 dihydrochloride
Lanicemine dihydrochloride
AR-R 15896 dihydrochloride
AZD6765 dihydrochloride >=97% (HPLC)
(αS)-α-Phenyl-2-pyridineethanamine dihydrochloride
ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 5mg | 600元 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | HY-108235A | ARL15896; ARL 15896; LANICEMINE HYDROCHLORIDE; AR-R15896AR Lanicemine dihydrochloride | 153322-06-6 | 10mg | 1050元 |
常見問題列表
生物活性
Lanicemine (AZD6765) dihydrochloride 是一種低捕獲的 NMDA 受體拮抗劑，Ki 為 0.56-2.1?μM。CHO 和爪蟾卵母細(xì)胞中，IC50 分別為 4-7 μM 和 6.4 μM。具有抗抑郁作用。靶點(diǎn)
NMDA receptor
體內(nèi)研究
Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects. Lanicemine (3, 10 or 30?mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 3, 10 or 30?mg/kg |
| Administration: | Intraperitoneal |
| Result: | Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity. |