15332-10-2
15332-10-2 結構式
基本信息
中文別名
化合物 T22720 英文別名
DFB3,3'-DIFLUOROBENZALDAZINE
3,3' Difluorobenzaldazine,3,3'Difluorobenzaldazine
[(3-FLUOROPHENYL)METHYLENE]HYDRAZONE-3-FLUOROBENZALDEHYDE
Benzaldehyde, 3-fluoro-, 2-[(3-fluorophenyl)methylene]hydrazone
1-(3-fluorophenyl)-N-[(Z)-(3-fluorophenyl)methylideneamino]methanimine
物理化學性質(zhì)
沸點326.6±42.0 °C(Predicted)
密度1.12±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMSO: ~12 mg/mL
酸度系數(shù)(pKa)5.78±0.50(Predicted)
形態(tài)solid
顏色yellow
常見問題列表
生物活性
3,3'-Difluorobenzaldazine (DFB) 是一種選擇性 mGluR5 正變構調(diào)節(jié)劑。3,3'-Difluorobenzaldazine 可增強 mGlu5 激動劑 (Glutamate, Quisqualate, 3,5-Dihydroxyphenylglycine) 的 3-6 倍作用，EC50 在 2 到 5 μM 范圍內(nèi)。體外研究
3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC 50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies.
體內(nèi)研究
3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine.
| Animal Model: | Male NMRI and ICR mice (8-9 weeks, 33-40 g) |
| Dosage: | 40-100 nmol (~9.7-24.4 μg) |
| Administration: | ICV |
| Result: | Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine. |