147388-83-8
中文名稱
3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]異惡唑鹽酸鹽
英文名稱
ABT-418 HYDROCHLORIDE
CAS
147388-83-8
分子式
C9H14N2O.ClH
分子量
202.684
MOL 文件
147388-83-8.mol
147388-83-8 結(jié)構(gòu)式
基本信息
中文別名
3-甲基-5-[(2S)-1-甲基-2-吡咯烷基]異惡唑鹽酸鹽 英文別名
ABT-418 HClABT-418 HYDROCHLORIDE
(S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazolea€￠HCl
3-Methyl-5-[(2S)-1-Methylpyrrolidin-2-yl]isoxazole hydrochloride
物理化學(xué)性質(zhì)
儲存條件-20°C
溶解度H2O: 15 mg/mL, soluble
形態(tài)solid
顏色white to off-white
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。蒸餾水溶液可在 -20°C 下保存長達 3 個月。
常見問題列表
生物活性
ABT-418 hydrochloride 是一種高效、選擇性的 nAChRs 激動劑，具有增強認知和抗焦慮的作用。ABT-418 hydrochloride 激活膽堿能通道，可用于阿爾茨海默病的研究。靶點
nAChRs
體內(nèi)研究
ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze.
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment.
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD.
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression.
| Animal Model: | Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model |
| Dosage: | 0.6 mg/kg |
| Administration: | Intraperitoneal injection; once daily; for two weeks |
| Result: | Effectively improved spatial memory. |