1470302-79-4
1470302-79-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T13417 英文別名
ZYZ-488β-D-Glucopyranosiduronic acid, 4-[[4-[(aminoiminomethyl)amino]butoxy]carbonyl]-2,6-dimethoxyphenyl
物理化學(xué)性質(zhì)
沸點700.6±70.0 °C(Predicted)
密度1.57±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 200 mg/mL (410.29 mM)
酸度系數(shù)(pKa)2.75±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
ZYZ-488 是一種競爭性凋亡蛋白酶激活因子-1 (Apaf-1) 抑制劑，抑制結(jié)合蛋白 procaspase-9 和 procaspase-3 的激活。靶點
Apoptotic protease activating factor-1
體外研究
ZYZ-488 decreases apoptosis in hypoxic H9c2 cells. ZYZ-488 inhibits hypoxia induced Apaf-1-mediated activation of procaspase-9 and procaspase-3.
ZYZ-488 decreases myocardial enzyme release, inhibits cardiomyocyte apoptosis, and suppresses the activation of the downstream cascade of caspases.
體內(nèi)研究
ZYZ-488 (33.9-67.8 mg/kg; intramuscularly; for 3 days) protected against myocardial apoptosis.
| Animal Model: | Male C57BL/6 mice (8-10 weeks old) |
| Dosage: | myocardial infarction?+?ZYZ-488 (33.9?mg/kg); myocardial infraction?+?ZYZ-488 (67.8?mg/kg); |
| Administration: | Intramuscularly; for 3 days |
| Result: | Inhibited Apaf-1-mediated activation of procaspase-9 and procaspase-3. |