14653-77-1
14653-77-1 結(jié)構(gòu)式
基本信息
硫代乙基氨基乙基胺鹽酸鹽
氨磷汀硫醇 USP標(biāo)準(zhǔn)品
2-[(3-氨基丙基)氨基]乙硫醇二鹽酸鹽
AMifostine Thiol
WR-1065 dihydrochloride
Amifostine Thiol Dihydrochloride
Amifostine Thiol Dihydrochloride (90%)
Amifostine Impurity 2（Amifostine Thiol）
2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride
2-[(3-Aminopropyl)amino]ethanethioldihydrochloride
2-[(3-aminopropyl)amino]ethane-1-thiol dihydrochloride
Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
p53
The DNA-binding activity is increased in a WR-1065 dihydrochloride (WR-1065) concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h reveal that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1, and a 5-fold increase when this reporter gene is driven by NF-κB, when these values are normalized to the level of the cotransfected β-galactosidase gene.
The results show that wR-1065 dihydrochloride (WR-1065) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that WR-1065 dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats.