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145854-59-7

中文名稱 ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
英文名稱 MAS 7
CAS 145854-59-7
分子式 C67H124N18O15
分子量 1421.81
MOL 文件 145854-59-7.mol
更新日期 2024/12/23 10:30:30
145854-59-7 結(jié)構(gòu)式 145854-59-7 結(jié)構(gòu)式

基本信息

中文別名
胡蜂蜂毒肽 7
英文別名
MAS 7
MASTOPARAN 7
INLKALAALAKALL-NH2
Mastoparan-7, ≥97% (HPLC)
MASTOPARAN 7 SYNTHETIC >98%
mastoparan from polistes jadwagae
MAS 7 - CAS 145854-59-7 - Calbiochem
Mastoparan-7 >=97% (HPLC), lyophilized powder
19: PN: WO2010069074 SEQID: 17 claimed protein
ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
所屬類別
生物化工:動物提取物

物理化學性質(zhì)

沸點1649.9±65.0 °C(Predicted)
密度1.154±0.06 g/cm3(Predicted)
儲存條件-20°C
酸度系數(shù)(pKa)13.43±0.46(Predicted)
形態(tài)lyophilized powder
顏色White to off-white

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
警示詞危險
危險性描述H317-H334
WGK Germany3
ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/01/25HY-P0258ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
Mas7
145854-59-71mg900元
2024/01/25HY-P0258ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
Mas7
145854-59-75mg3600元
2024/01/25HY-P0258ILE-ASN-LEU-LYS-ALA-LEU-ALA-ALA-LEU-ALA-LYS-ALA-LEU-LEU-NH2
Mas7
145854-59-710mg5600元

常見問題列表

生物活性
Mas7 (Mastoparan 7) 是 mastoparan 的結(jié)構(gòu)類似物,是異源三聚體 Gi 蛋白及其下游效應物的活化劑。
體外研究

Mas7 (Mastoparan 7) produces several biological effects in different cell types. The effect of Mas7 on endogenous mono-ADP-ribosyltransferase activity is in the micromolar range with a maximal activation of 205% over the basal. In pertussis treated plasma membranes, it is found that the effect of Mas7 on endogenous mono-ADP-ribosyltransferase is partially blocked, which suggests the involvement of G-proteins, such as Gi or G0.
Mas7 is a basic tetradecapeptide isolated from isp venom, which activates guanine nucleotide-binding regulatory proteins (G-proteins) and stimulates apoptosis. In smooth muscle cells, Mas7 leads to an increase in the perfusion pressure. Vascular contraction is induced by Mas7. The vasoconstriction triggered by mas-7 exhibited a slower increase compared to that simulated by phenylephrine or vasopressin.
Exposure of hippocampal neurons to a low dose of Mas-7 increases dendritic spine density and spine head width in a time-dependent manner. Additionally, Mas-7 enhances postsynaptic density protein-95 (PSD-95) clustering in neurites and activates Gαo signaling, increasing the intracellular Ca 2+ concentration.

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