145337-55-9
145337-55-9 結構式
基本信息
中文別名
化合物 T12762 英文別名
GI4747Ro 31-9790
Butanediamide, N1-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N4-hydroxy-2-(2-methylpropyl)-, (2R)-
常見問題列表
生物活性
Ro 31-9790 是一種合成的金屬蛋白酶 (MMP) 抑制劑。靶點
MMP
體外研究
Ro 31-9790 inhibits L-selectin shedding from mouse and human lymphocytes, Jurkat T cells, and human monocytes with an IC 50 of 0.3-0.4 μM on these cell types. The IC 50 values obtained for Ro 31-9790 are 4.82?±?0.75 μM, 1.16?±?0.27 μM, 0.70?±?0.06 μM, 4.47±?1.27 μM and 0.38?±?0.05 μM for mouse lymphocyte L-selectin shedding, Jurkat L-selectin shedding, human lymphocyte L-selectin shedding, human monocyte L-selectin shedding and human monocyte TNF-α shedding.