145196-87-8
中文名稱
Iodophenpropit dihydrobromide
英文名稱
Iodophenpropit dihydrobromide
CAS
145196-87-8
分子式
C15H19IN4S.2HBr
分子量
495.22
MOL 文件
145196-87-8.mol
145196-87-8 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:50.0(Max Conc. mg/mL);86.79(Max Conc. mM)
Water:32.2(Max Conc. mg/mL);55.89(Max Conc. mM)
Water:32.2(Max Conc. mg/mL);55.89(Max Conc. mM)
形態(tài)粉末
顏色White to off-white
水溶解性Soluble to 25 mM in water
常見問題列表
生物活性
Iodophenpropit dihydrobromide 是一種有效的選擇性組胺 H3 受體 (histamine H3 receptor) 拮抗劑。[125I] Iodophenpropit 結(jié)合 H3 受體具有選擇性，可飽和，易于可逆，及高親和力 (KD 為 0.32 nM)。靶點(diǎn)
|
H 3 Receptor 0.32 nM (Kd) |
體外研究
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC
50
of 1.57±0.3 μM.
體內(nèi)研究
Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.
| Animal Model: | New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg |
| Dosage: | 1 μg/kg |
| Administration: | Administered through intramuscular (i.m.); b.i.d.; for 10 days |
| Result: | Could influence a detectable antibody response to SRBC. |