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1443246-62-5

中文名稱 1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
英文名稱 VU0456810
CAS 1443246-62-5
分子式 C17H14F2N4O
分子量 328.32
MOL 文件 1443246-62-5.mol
更新日期 2024/12/23 17:39:05
1443246-62-5 結(jié)構(gòu)式 1443246-62-5 結(jié)構(gòu)式

基本信息

中文別名
化合物ML297
英文別名
ML297
VU0456810
CID 56642816
ML297 (VU0456810)
ML297 >=98% (HPLC)
ML297, Pubchem: CID 56642816
ML 297 (Synonyms: VU 0456810
ML 297
ML-297
ML297
VU0456810
VU-0456810
VU 0456810
GIRK Activator, ML297 - CAS 1443246-62-5 - Calbiochem
1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA

物理化學(xué)性質(zhì)

沸點(diǎn)377.8±42.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,Store in freezer, under -20°C
溶解度DMSO:可溶15mg/mL,澄清
酸度系數(shù)(pKa)12.54±0.70(Predicted)
形態(tài)白色粉末
顏色白色至米色
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS09
警示詞警告
危險(xiǎn)性描述H410
防范說(shuō)明P273-P501
危險(xiǎn)品標(biāo)志N
危險(xiǎn)類別碼50/53
安全說(shuō)明60-61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-1101921-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
ML 297
1443246-62-55mg700元
2024/11/08HY-1101921-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
ML 297
1443246-62-510mM * 1mLin DMSO770元
2024/11/08HY-1101921-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA
ML 297
1443246-62-510mg1100元

常見(jiàn)問(wèn)題列表

生物活性
ML-297 (VU 0456810, CID 56642816)是一種有效的、選擇性的 Kir3.1/3.2 (G protein-coupled inwardly rectifying potassium, GIRK1/2) 通道的激活劑,其對(duì)于GIRK1/2和GIRK1/4的EC50值分別為0.16 μM和1.8 μM。ML-297 具有治療癲癇的潛力。
靶點(diǎn)
TargetValue
GIRK1/2
(Cell-free assay)
0.16 μM
GIRK1/4
(Cell-free assay)
1.8 μM
體外研究

ML 297 is completely inactive for GIRK 2/3 .
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC 50 of 162 nM.
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK 2 alone and GIRKGIRK 2/3 .

體內(nèi)研究

ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment.

Animal Model: 8-10 months old C57/BL6 male mice (approximately 30 g)
Dosage: 60 mg/kg
Administration: Intraperitoneal injection
Result: Most of the animals neither convulsions nor death.
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