1431698-47-3
中文名稱
KN-92 鹽酸鹽
英文名稱
KN-92 (hydrochloride)
CAS
1431698-47-3
分子式
C24H26Cl2N2O3S
分子量
493.446
MOL 文件
1431698-47-3.mol
更新日期
2024/07/24 18:26:22
1431698-47-3 結(jié)構(gòu)式
基本信息
中文別名
KN-92 鹽酸鹽 英文別名
CS-1448KN92-HCl
KN-92 (hydrochloride)
KN 92 HYDROCHLORIDE
KN92 HYDROCHLORIDE
所屬類別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
儲(chǔ)存條件Inert atmosphere,Store in freezer, under -20°C
溶解度≥24.65 mg/mL in DMSO; insoluble in H2O; ≥11.73 mg/mL in EtOH with gentle warming and ultrasonic
形態(tài)固體
顏色White to off-white
常見問題列表
生物活性
KN-92 hydrochloride 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 hydrochloride 可作為對(duì)照化合物用于闡明 KN-93 的拮抗活性。KN-93 可滲透細(xì)胞，可逆和競(jìng)爭(zhēng)性的 CaMKII 抑制劑。體外研究
KN-93 (5-50μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth.
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21.
Cell Viability Assay
| Cell Line: | Human hepatic stellate cells (LX-2) |
| Concentration: | 5-50 μM |
| Incubation Time: | 24 hours |
| Result: | Ineffective in blocking cell growth. |