1430218-51-1
中文名稱
1430218-51-1
英文名稱
VI16832
CAS
1430218-51-1
分子式
C22H25N5O2
分子量
391.47
MOL 文件
1430218-51-1.mol
更新日期
2024/06/17 17:25:38
1430218-51-1 結(jié)構(gòu)式
基本信息
中文別名
I型激酶抑制劑(VI 16832) 英文別名
VI16832Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-[[4-(2-aminoethoxy)phenyl]amino]-8-bicyclo[2.2.1]hept-2-yl-
物理化學(xué)性質(zhì)
沸點(diǎn)611.9±65.0 °C(Predicted)
密度1.337±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 83.3 mg/mL (212.79 mM)
酸度系數(shù)(pKa)8.57±0.10(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
1430218-51-1價(jià)格(試劑級)
| 報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 1mg | 990元 |
| 2024/11/08 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 5mg | 3150元 |
| 2024/11/08 | HY-18623 | 1430218-51-1 VI 16832 | 1430218-51-1 | 10mM * 1mLin DMSO | 3465元 |
常見問題列表
生物活性
VI 16832 是一種廣譜的 I 型激酶抑制劑，可用作不同癌細(xì)胞系中蛋白激酶比較表達(dá)分析的富集工具。靶點(diǎn)
Type I kinase
體外研究
VI 16832 is a broad spectrum Type I kinase inhibitor. Phosphoproteomics analysis of VI 16832-enriched fractions from MV4-11, HCT116, or 435S cells results in more than 8500 phosphopeptide identifications. These translate into almost 1700 distinct phosphopeptide species derived from 212 different members of the protein kinase superfamily. Analysis of VI 16832-retained proteins from the three cancer cell lines considerably increases the overall number of identified phosphorylation sites on protein kinases. Considering the sum of all phosphopeptide intensities as a measure for VI 16832-enriched protein amount, more than 80% is derived from protein kinases.