1428774-45-1
中文名稱
化合物PF-06459988
英文名稱
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
CAS
1428774-45-1
分子式
C19H22ClN7O3
分子量
431.88
MOL 文件
1428774-45-1.mol
1428774-45-1 結(jié)構(gòu)式
基本信息
中文別名
化合物PF-06459988 英文別名
EOS-61635PF-06459988
PF-06459988 >=98% (HPLC)
1-((3R,4R)-3-(((5-chloro-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
irreversible,oral,T790M,Inhibitor,EGFR,PF 06459988,PF-06459988,HER1,NSCLC,inhibit,PF06459988,Epidermal growth factor receptor,cancer,ErbB-1
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
2-Propen-1-one, 1-[(3R,4R)-3-[[[5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]-
物理化學(xué)性質(zhì)
密度1.50±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO : 50 mg/mL (115.77 mM)
酸度系數(shù)(pKa)11.26±0.50(Predicted)
形態(tài)Solid
顏色White to off-white