142873-41-4
中文名稱
142873-41-4
英文名稱
5-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-
CAS
142873-41-4
分子式
C24H32N2O
分子量
364.52
MOL 文件
142873-41-4.mol
142873-41-4 結(jié)構(gòu)式
基本信息
中文別名
脂質(zhì)過(guò)氧化抑制劑1 英文別名
Lipid peroxidation inhibitor 15-Benzofuranamine, 2,3-dihydro-2,4,6,7-tetramethyl-2-[(4-phenyl-1-piperidinyl)methyl]-
物理化學(xué)性質(zhì)
沸點(diǎn)520.4±50.0 °C(Predicted)
密度1.090±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)8.09±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
Lipid peroxidation inhibitor 1 是一種脂質(zhì)過(guò)氧化 (lipid peroxidation) 抑制劑，其 IC50 值為 0.07 μM。靶點(diǎn)
IC50: 0.07μM (lipid peroxidation)
體外研究
Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC 50 of 0.07 μM.
體內(nèi)研究
Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective.