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1428307-52-1

英文名稱 MRT-92 HCl salt
CAS 1428307-52-1
分子式 C33H35ClN4O5
分子量 603.12
MOL 文件 1428307-52-1.mol
1428307-52-1 結(jié)構(gòu)式 1428307-52-1 結(jié)構(gòu)式

基本信息

英文別名
MRT-92 HCl salt

應(yīng)用領(lǐng)域

用途一
MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs that bind to a long and narrow cavity in the 7-transmembrane (7TM) domain.
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