142439-94-9
中文名稱
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
英文名稱
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CAS
142439-94-9
分子式
C10H11N5NaO5PS
分子量
367.25
MOL 文件
142439-94-9.mol
更新日期
2023/03/20 15:41:19
142439-94-9 結(jié)構(gòu)式
基本信息
英文別名
RP-CAMPS NACAMPS NA RP-ISOMER
RP-CAMPS SODIUM SALT
SP-CYCLIC 3,5-HYDROGEN PHOSPHOROTHIOATE ADENOSINE SODIUM SALT
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT
ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at -20°C, sealed storage, away from moisture and light
形態(tài)Solid
顏色White to pink
常見(jiàn)問(wèn)題列表
生物活性
Rp-cAMPS sodium salt，一種 cAMP 的類似物，是一種 cAMP 誘導(dǎo)的 PKA I 和 PKA II 活化 (Ki 分別為 12.5 μM 和 4.5 μM) 的有效的，競(jìng)爭(zhēng)性拮抗劑。Rp-cAMPS sodium salt 耐磷酸二酯酶水解。靶點(diǎn)
Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)
體外研究
A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.
體內(nèi)研究
Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.