1422826-80-9
1422826-80-9 結(jié)構(gòu)式
基本信息
英文別名
APTO-253
(APTO2531H-Imidazo[4,5-f][1,10]phenanthroline, 2-(6-fluoro-2-methyl-1H-indol-3-yl)-
應(yīng)用領(lǐng)域
用途一
APTO-253 isomer is an isomer of APTO-253 with the Fluoro-atom in 6-position. APTO-253 also known as LOR-253, LT-253, is a small molecule inhibitor of human metal-regulatory transcription factor 1 (MTF-1) with potential antitumor activity. MTF-1 inhibitor LOR-253 inhibits MTF-1 activity and thereby induces the expression of MTF-1 dependent tumor suppressor factor Kruppel like factor 4 (KLF4). This subsequently leads to the downregulation of cyclin D1, blocking cell cycle progression and proliferation. This agent also causes decreased expression of genes involved in tumor hypoxia and angiogenesis.