1421837-45-7
物理化學(xué)性質(zhì)
沸點693.8±55.0 °C(Predicted)
密度1.150±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 62.5 mg/mL (137.50 mM)
酸度系數(shù)(pKa)14.55±0.46(Predicted)
形態(tài)Solid
顏色White to off-white
TMP920價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 5mg | 800元 |
| 2024/11/08 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 10mM * 1mLin DMSO | 880元 |
| 2024/11/08 | HY-117819 | TMP920 TMP920 | 1421837-45-7 | 10mg | 1300元 |
常見問題列表
生物活性
TMP920 是一個高效、選擇性的 RORγt 拮抗劑。TMP920 抑制 RORγt 結(jié)合 SRC1 肽的 IC50 值為 0.03 μM。靶點
IC50: 0.03 μM (RORγt)
體外研究
TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Na?ve CD4
+
T cells.
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro.
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro.
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets.
TMP920 significantly reduces RORγt-DNA interactions.
Cell Cytotoxicity Assay
| Cell Line: | Na?ve CD4 + T cells |
| Concentration: | 0.09-30 μM |
| Incubation Time: | 48 hours |
| Result: | Has toxic effects on cell growth at >10 μM. |