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1420071-13-1

中文名稱 LAS191859
英文名稱 LAS191859
CAS 1420071-13-1
分子式 C24H24F3N3O3
分子量 459.46
MOL 文件 1420071-13-1.mol
1420071-13-1 結(jié)構(gòu)式 1420071-13-1 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27799
英文別名
LAS191859
1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, 1-[2-[[(cyclopropylcarbonyl)ethylamino]methyl]-4-(trifluoromethyl)phenyl]-6-methyl-

物理化學性質(zhì)

儲存條件-20°C儲存
溶解度DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 2.5 mg/ml
形態(tài)結(jié)晶固體

應用領(lǐng)域

用途一
LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 9.58, 14, 15.5, and 7.6 nM for recombinant human, rat, mouse, and guinea pig CRTH2/DP2 receptors, respectively. In vitro evidence in GTPγS binding studies indicate that LAS191859 is a CRTh2 antagonist with activity in the low nanomolar range. This potency is also maintained in cellular assays performed with human eosinophils and whole blood. The main differentiation of LAS191859 vs other CRTh2 antagonists is in its receptor binding kinetics. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasting in vivo efficacy that is independent of plasma levels
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