142001-63-6
142001-63-6 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16842 英文別名
SR 48968Sr 48968c
(S)-N-Methyl-N(4-(4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl)butyl)benzamide
Benzamide, N-((2S)-4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-
Benzamide, N-(4-(4-(acetylamino)-4-phenyl-1-piperidinyl)-2-(3,4-dichlorophenyl)butyl)-N-methyl-, (S)-
物理化學(xué)性質(zhì)
沸點(diǎn)734.7±60.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO: 250 mg/mL (452.46 mM)
酸度系數(shù)(pKa)15.88±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Saredutant 是一種選擇性 NK2 受體拮抗劑。靶點(diǎn)
|
NK2
|
體內(nèi)研究
Saredutant, an NK2 receptor antagonist, has both antidepressant-like effects and synergizes with desipramine in an animal model of depression. Saredutant has dose-dependent effects on swim test immobility, with the low dose of 1 mg/kg having no effect and the doses of 3 and 10 mg/kg significantly reducing immobility.