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141676-35-9

中文名稱 Vasonatrin Peptide (VNP)
CAS 141676-35-9
分子式 C124H198N36O36S3
141676-35-9 結(jié)構(gòu)式 141676-35-9 結(jié)構(gòu)式

基本信息

英文別名
Vasonatrin Peptide (VNP)
H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
GLY-LEU-SER-LYS-GLY-CYS-PHE-GLY-LEU-LYS-LEU-ASP-ARG-ILE-GLY-SER-MET-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR ((DISULFIDE BRIDGE: CYS6-CYS22)
Vasonatrin Peptide (VNP) 價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2023/03/20HY-P1556Vasonatrin Peptide (VNP)
Vasonatrin Peptide (VNP)
141676-35-9500μg2000元
2023/03/20HY-P1556Vasonatrin Peptide (VNP)
Vasonatrin Peptide (VNP)
141676-35-91mg3600元
2023/03/20HY-P1556Vasonatrin Peptide (VNP)
Vasonatrin Peptide (VNP)
141676-35-95mg9900元

常見問題列表

生物活性
Vasonatrin peptide (VNP) 是心房鈉尿肽 (ANP) 和C型利尿鈉肽 (CNP) 的嵌合體,具有高效的靜脈擴(kuò)張和利鈉活性。
靶點(diǎn)

Natriuretic peptide receptors

體外研究

Vasonatrin peptide binds with both natriuretic peptide receptor A and B, but with a preference for B. VNP-stimulated cGMP is 11-fold greater in NPRB than NPRA.

體內(nèi)研究

The high-fat diet-fed streptozotocin-induced diabetic Sprague-Dawley rats are subjected to ischemia-reperfusion operation. VNP treatment (100 g/kg iv, 10 min before reperfusion) significantly improved the instantaneous first derivation of left ventricle pressure (LV dP/dtmax) and LV systolic pressure and reduced LV end-diastolic pressure, apoptosis index, caspase-3 activity, plasma creatine kinase (CK), and lactate dehydrogenase (LDH) activities. Treatment hypoxia-induced pulmonary hypertension (HPH) with Vasonatrin peptide for 1 week significantly reduceS mean pulmonary arterial pressure, pulmonary vascular resistance, RVH and muscularization of the pulmonary arteries. Acute intravenous administration of 50 microg/kg Vasonatrin peptide significantly ameliorates pulmonary haemodynamics in HPH rats.

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