1383478-94-1
中文名稱
CYM 9484
英文名稱
N-[4-[(DiMethylaMino)sulfonyl]phenyl]-4-(hydroxydiphenylMethyl)-1-piperidinecarbothioaMide
CAS
1383478-94-1
分子式
C27H31N3O3S2
分子量
509.68
MOL 文件
1383478-94-1.mol
1383478-94-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10921 英文別名
CYM 9484N-[4-[(DiMethylaMino)sulfonyl]phenyl]-4-(hydroxydiphenylMethyl)-1-piperidinecarbothioaMide
1-Piperidinecarbothioamide, N-[4-[(dimethylamino)sulfonyl]phenyl]-4-(hydroxydiphenylmethyl)-
常見問題列表
生物活性
CYM 9484 是一種選擇性強效神經(jīng)肽 Y (NPY) Y2 受體拮抗劑，IC50 值為 19 nM。靶點
|
NPYY 2 receptor 19 nM (IC 50 ) |
體外研究
SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC 50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates.