1374601-41-8
中文名稱
BRD9539
英文名稱
BRD-9539
CAS
1374601-41-8
分子式
C24H21N3O3
分子量
399.44
MOL 文件
1374601-41-8.mol
更新日期
2024/12/22 21:55:00
1374601-41-8 結(jié)構(gòu)式
基本信息
中文別名
G9A和PRC2抑制劑(BRD9539) 英文別名
BRD9539BRD 9539
BRD-9539
2-(BenzoylaMino)-1-(3-phenylpropyl)-1H-benziMidazole-5-carboxylic acid
1H-Benzimidazole-5-carboxylic acid, 2-(benzoylamino)-1-(3-phenylpropyl)-
所屬類別
生物化工：激動(dòng)劑抑制劑安全數(shù)據(jù)
BRD9539價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 5mg | 600元 |
| 2024/11/08 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 10mM * 1mLin DMSO | 660元 |
| 2024/11/08 | HY-15647 | BRD9539 BRD9539 | 1374601-41-8 | 10mg | 990元 |
常見問(wèn)題列表
生物活性
BRD9539 是一種組蛋白甲基轉(zhuǎn)移酶 G9a 抑制劑，IC50 為 6.3 μM。BRD9539 還抑制 PRC2 活性，并且對(duì) SUV39H1，NSD2 和 DNMT1 無(wú)活性。靶點(diǎn)
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G9a 6.3 μM (IC 50 ) |
PRC2
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體外研究
BRD9539 decreases ATP levels in a dose-dependent manner in HeLa cells.
BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration. However, BRD9539 has no activity in cell-based assays, presumably due to impaired cell permeability compared to that of BRD4770. In addition, the activities of 16 other chromatin-modifying enzymes and 100 kinases involved in cell-cycle regulation and cancer cell biology are tested for activity in the presence of 5 or 10 μM BRD9539; no activity is seen in any of these assays.