137213-91-3
137213-91-3 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點378.8±22.0 °C(Predicted)
密度1.20±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)15.48±0.40(Predicted)
常見問題列表
生物活性
(4-Acetamidocyclohexyl) nitrate (BM121307) 是一種鳥苷酸環(huán)化酶 (guanylate cyclase) 激活劑。體內(nèi)研究
The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively.