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137213-91-3

中文名稱 137213-91-3
CAS 137213-91-3
分子式 C8H14N2O4
分子量 202.21
MOL 文件 137213-91-3.mol
137213-91-3 結(jié)構(gòu)式 137213-91-3 結(jié)構(gòu)式

基本信息

英文別名
(4-acetamidocyclohexyl) nitrate
Acetamide, N-[trans-4-(nitrooxy)cyclohexyl]-

物理化學(xué)性質(zhì)

沸點378.8±22.0 °C(Predicted)
密度1.20±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)15.48±0.40(Predicted)

常見問題列表

生物活性
(4-Acetamidocyclohexyl) nitrate (BM121307) 是一種鳥苷酸環(huán)化酶 (guanylate cyclase) 激活劑。
體內(nèi)研究

The elimination of BM121307 and its metabolites via urine and feces amount to 76.5% after oral application, and to 80.7% of the applied dose after intravenous application. The major amount of radioactivity is eliminated via urine (69.4% and 73.6% of the dose, respectively), whereas the fecal elimination is found to be negligible. Investigations of the urinary samples show that the drug is metabolized to a high percentage trans-N-(4-Hydroxycyclohexyl) acetamide is the main metabolite; 73% of the radioactive compounds (after p.o.-administration and 69% after intravenous application could be identified as the alcohol of BM121307; the amounts of the drug totaled 9% and 13%, respectively.

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