136609-26-2
136609-26-2 結構式
基本信息
中文別名
化合物 T12767化合物RP 70676
RP 70676游離態(tài)
英文別名
RP 706761H-Pyrazole, 1-[5-[(4,5-diphenyl-1H-imidazol-2-yl)thio]pentyl]-3,5-dimethyl-
所屬類別
生物化工：抑制劑物理化學性質
沸點605.9±57.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)11.80±0.10(Predicted)
形態(tài)固體
顏色白色至灰白色
常見問題列表
生物活性
RP 70676 是一種有效的 ACAT 抑制劑，能夠抑制對大鼠和兔子中的 ACAT 活性，IC50 值分別為 25 和 44 nM。靶點
IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
體外研究
RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC 50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC 50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC 50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC 50 of 540 nM.
體內(nèi)研究
RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits.