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1366000-58-9

中文名稱 ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
英文名稱 Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Acetate)
CAS 1366000-58-9
更新日期 2024/12/22 20:23:43
分子式 C129H207N45O41S3
分子量 3140.53
MOL 文件 1366000-58-9.mol
1366000-58-9 結(jié)構(gòu)式 1366000-58-9 結(jié)構(gòu)式

基本信息

中文別名
化合物 TP1219
英文別名
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine (Acetate)
所屬類別
生物:多肽激素

物理化學(xué)性質(zhì)

儲存條件-20°C儲存
形態(tài)Solid
顏色White to off-white
水溶解性25mg/ml in Water
序列H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH (Disulfide bridge: Cys7-Cys23)
ATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2022/04/29HY-P1235AATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
1366000-58-9500μg1800元
2022/04/29HY-P1235AATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
1366000-58-91mg2800元
2022/04/29HY-P1235AATRIAL NATRIURETIC PEPTIDE (ANP) (1-28), HUMAN, PORCINE ACETATE
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
1366000-58-95mg9800元

常見問題列表

生物活性
Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate 是一種含 28 個氨基酸的激素,由心臟產(chǎn)生并分泌,以響應(yīng)心臟損傷和機械拉伸。ANP (1-28) 抑制內(nèi)皮素-1 (endothelin-1) 分泌。
靶點

Endothelin-1

體外研究

Atrial natriuretic peptide (ANP) is a diuretic, natriuretic, and vasodilatory peptide hormone originally isolated from mammalian hearts. In cultured porcine endothelial cells the inhibition by porcine ANP (1-28) of immunoreactive endothelin-1 secretion after stimulation with Angiotensin II (Ang II) is paralleled by an increase in the cellular cGMP level. Porcine ANP (1-28) strongly inhibits immunoreactive endothelin-1 secretion in porcine aorta after stimulation with Ang II. ANP is a cardiac hormone involved in electrolyte and fluid homeostasis. The inhibition by ANP of endothelin-1 secretion stimulated by angiotensin II (ANGII) and thrombin using cultured human umbilical-vein endothelial cells. Human ANP (1-28) inhibits immunoreactive (ir)-endothelin-1 secretion and increases cyclic GMP in the human umbilical-vein endothelial cells. In glomeruli from normal rats, Human 125 I-ANP (1-28) binds to a single population of high affinity receptors with a mean equilibrium dissociation constant of 0.46 nM. Human ANP (1-28) binds to the glomerular ANP receptor with high affinity stimulated cGMP accumulation. Human ANP (1-28) markedly stimulates cGMP generation, but not cAMP generation in normal rat glomeruli.

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