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136451-58-6

英文名稱 BMY 42393
CAS 136451-58-6
分子式 C25H21NO4
分子量 399.44
MOL 文件 136451-58-6.mol
136451-58-6 結(jié)構(gòu)式 136451-58-6 結(jié)構(gòu)式

基本信息

英文別名
BMY 42393

應(yīng)用領(lǐng)域

用途一
BMY-42393 is orally active and selective platelet aggregation inhibitor. BMY-42393 is also a prostacyclin partial agonist that inhibited ADP, collagen and thrombin-induced platelet aggregation (IC50 range 0.3 - 2.0 microM). BMY-42393 stimulated platelet adenylate cyclase activity (EC50 = 25 nM). Platelets treated with BMY 42393 showed an elevation of cAMP levels and activation of cAMP-dependent protein kinase. BMY 42393 also inhibited thrombin-induced elevation of intracellular free calcium. BMY 42393 competed for radiolabeled iloprost and PGE1 binding to platelet membranes (IC50; 170 nM and 130 nM, respectively).
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