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1361644-26-9

中文名稱 ALDOXORUBICIN
英文名稱 INNO206
CAS 1361644-26-9
分子式 C37H42N4O13
分子量 750.75
MOL 文件 1361644-26-9.mol
更新日期 2024/11/15 18:20:30
1361644-26-9 結(jié)構(gòu)式 1361644-26-9 結(jié)構(gòu)式

基本信息

中文別名
(E)-N'-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-氨基-5-羥基-6-甲基-2-四氫吡喃基]氧基]-2,5,12-三羥基-7-甲氧基-6,11-二氧代-1,2,3,4,6,11-六氫-2-并四苯基]-2-羥基亞乙基]-6-(2,5-二氧代-2,5-二氫-1-吡咯基)己酰肼
英文別名
Aldoxorubicin
Aldoxorubicin (INNO-206)
Aldoxorubicin Aldoxorubicin
N-[(E)-[1-[(2S,4S)-4-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]-2-hydroxyethylidene]amino]-6-(2,5-dioxopyrrol-1-yl)hexanamide
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, (2E)-2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]-2-hydroxyethylidene]hydrazide
(E)-N’-[1-[(2S,4S)-4-[[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-2-tetrahydropyranyl]oxy]-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-2-tetracenyl]-2-hydroxyethylidene]-6-(2,5-dioxo-2,5-dihydro-1-pyrrolyl)hexanehydrazide

物理化學(xué)性質(zhì)

密度1.60±0.1 g/cm3(Predicted)
儲(chǔ)存條件-80°, stored under nitrogen,unstable in solution, ready to use.
溶解度DMSO : 75 mg/mL (99.90 mM)
酸度系數(shù)(pKa)7.36±0.60(Predicted)
形態(tài)Solid
顏色Purple to purplish red

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS08
警示詞危險(xiǎn)
危險(xiǎn)性描述H340-H350-H360
ALDOXORUBICIN價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-16261ALDOXORUBICIN
Aldoxorubicin
1361644-26-92mg750元
2024/11/08HY-16261ALDOXORUBICIN
Aldoxorubicin
1361644-26-95mg1200元
2024/11/08HY-16261ALDOXORUBICIN
Aldoxorubicin
1361644-26-910mg1740元

常見問題列表

生物活性
Aldoxorubicin (INNO-206) 是多柔比星 (DNA 拓?fù)洚悩?gòu)酶 II 抑制劑) 的白蛋白結(jié)合前藥,在酸性條件下從白蛋白中釋放出來。 Aldoxorubicin (INNO-206) 在各種癌細(xì)胞系和小鼠腫瘤模型中具有有效的抗腫瘤活性。
靶點(diǎn)

Topoisomerase II

Daunorubicins/Doxorubicins

體外研究

Aldoxorubicin (INNO-206) (0.27 to 2.16 μM) inhibits blood vessel formation and reduces multiple myeloma cell growth in a pH-dependent fashion.

體內(nèi)研究

Aldoxorubicin (INNO-206) (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor. Aldoxorubicin (INNO-206) shows a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study. Aldoxorubicin (INNO-206) shows superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models.

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